MAGE family member A13, pseudogene (MAGEA13P)

MAGE family member A13, pseudogene (MAGEA13P) is annotated as a pseudogene within the MAGE (Melanoma Antigen Gene) family. Canonical MAGE proteins are classified into type I (MAGE-A, -B, -C) and type II (MAGE-D, -E, -F, -G, -H, -L, Necdin) families and are involved in protein ubiquitination, cancer/testis antigenicity, regulation of cell cycle, apoptosis, and tumorigenesis by interaction with E3 ubiquitin ligases[1][2][3]. However, MAGEA13P is specifically designated as a "pseudogene"—meaning it is a non-functional genomic DNA sequence similar to an active gene, but typically does not encode a functioning protein or have a known biological role[1]. There is no scientific evidence that MAGEA13P itself is expressed as a functional protein, contributes to a disease process, or serves as a therapeutic target. It is distinct from other functionally active MAGE-A proteins, such as MAGE-A11 or MAGE-A3, which are active in cancers and have established biological and disease roles[1][2][3]. No drugs or specific biomarkers are associated with MAGEA13P. As a pseudogene, MAGEA13P is not considered a relevant molecular or therapeutic target, has no established biological function, and does not play a recognized role in human disease. The name can cause confusion with functional MAGE-A family members involved in cancer, but MAGEA13P itself is non-coding and should not be considered a protein-coding target.

Other names

Putative MAGE domain-containing protein MAGEA13PMAGEA13PLOC139363