MAGI1 intronic transcript 1 (non-protein coding) (MAGI1-IT1)

MAGI1 intronic transcript 1 (MAGI1-IT1) is a long non-coding RNA (lncRNA) transcribed from the intronic region of the MAGI1 gene[5][6]. It does not encode a protein but functions as a regulator of gene expression through interactions with specific microRNAs. In epithelial ovarian cancer, MAGI1-IT1 is upregulated in metastatic tissue and promotes cell migration and invasion by sponging miR-200a and upregulating EMT-related genes ZEB1 and ZEB2; high MAGI1-IT1 expression is associated with later-stage disease and increased metastasis[1]. In the context of cardiovascular disease, MAGI1-IT1 is downregulated in models of cardiac hypertrophy, and its overexpression attenuates hypertrophy and fibrosis, likely through inhibition of Wnt/β-catenin signaling via the miR-302e/DKK1 axis[2][4][6][7]. It is implicated in multiple pathological processes, especially cancer metastasis and cardiac remodeling, but is not classified as a typical drug target such as a receptor or enzyme. To date, no approved or clinical-stage therapies directly target MAGI1-IT1, but it may serve as a potential biomarker or candidate for future therapeutic modulation.

Other names

MAGI1-IT1MAGI1 intronic transcript 1MAGI1 intronic transcript 1 (non-protein coding)lncRNA MAGI1-IT1

Acts as a molecular "sponge" for specific microRNAs such as miR-200a (in ovarian cancer) and miR-302e (in cardiac hypertrophy), thereby regulating the expression of target genes (e.g., ZEB1, ZEB2, DKK1). Regulates downstream signaling pathways, e.g., Wnt/β-catenin pathway, by modulating upstream miRNAs and their targets.