Mago homolog, exon junction complex subunit (MAGOH)

MAGOH is a highly conserved, small protein that forms the core of the exon junction complex (EJC), a multiprotein assembly deposited on mature mRNA approximately 20 nucleotides upstream of exon-exon junctions following splicing[1][3][5]. It tightly binds to Y14 (RBM8A) and interacts with the mRNA export factor TAP, but not with other EJC components directly[3][5]. MAGOH is essential for post-splicing mRNA processing, including nuclear export, cytoplasmic localization, and particularly nonsense-mediated mRNA decay. It remains associated with mRNA after export from the nucleus[3][5]. In model organisms, loss of magoh results in severe developmental defects and embryonic lethality, underlining its fundamental importance[3]. In humans, MAGOH is not considered a traditional therapeutic target (such as a receptor or enzyme), but is vital for cellular RNA metabolism. No small-molecule drugs are known to modulate its activity.

Other names

Protein mago nashi homologMAGOHAMAGOH1mago-nashi homologmago homologexon junction complex core componentproliferation-associated protein MAGOH

MAGOH is not directly targeted by drugs; its function is structural and regulatory within the exon junction complex[2][3]