Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1)

Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) is the alpha-chain subunit of the HLA-DP molecule, a heterodimeric MHC class II cell surface receptor expressed on antigen-presenting cells such as B lymphocytes, dendritic cells, and macrophages[1][4][5]. Together with its beta-chain partner (HLA-DPB1), it binds peptides derived from extracellular antigens and presents them to CD4+ T lymphocytes, playing a crucial role in adaptive immune responses and immune regulation[1][2][4]. The gene encoding HLA-DPA1 is highly polymorphic, contributing to the diversity of immune recognition[2]; specific alleles of HLA-DPA1 have been associated with susceptibility to autoimmune conditions, infectious disease outcomes, and transplantation compatibility[2][3]. Because of its central function in antigen presentation, HLA-DPA1 is a critical immunological target in clinical contexts such as transplantation, vaccine response, autoimmunity, and infectious diseases[2][3].

Other names

HLA class II histocompatibility antigen, DP alpha 1 chainDPA1HLA-DP1AHLASBDP(W3)DP(W4)HLA-SB alpha chainMHC class II DP3-alphaMHC class II DPA1HLA-DPAHLADPHLA-DPB1PLT1MHC class II antigen DP alpha chainMHC class II protein