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Major histocompatibility complex, class II, DP alpha 3 (pseudogene) (HLA-DPA3)

Target: HLA-DPA3
Molecular classification: Other (pseudogene; not a functional protein, receptor, or enzyme)

Overview

HLA-DPA3 is classified as a pseudogene within the human major histocompatibility complex (MHC) class II region, specifically mapped between HLA-DRA and HLA-DPA3 on chromosome 6[3]. Unlike other class II molecules (such as HLA-DR, HLA-DQ, HLA-DP functional alpha and beta chains) that present peptide antigens to T cells as part of the adaptive immune response, HLA-DPA3 does not encode a functional protein and has no known biological activity[1]. There are no known roles in disease, no drug interactions, and it is not considered a valid therapeutic or diagnostic target. This entry may arise from confusion with other functional HLA-DP alpha genes (such as HLA-DPA1), which are truly involved in immune presentation[1][3].

Other names: HLA-DPA3MHC class II DP alpha 3 (pseudogene)

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