Major Histocompatibility Complex (MHC) (MHC)

Major Histocompatibility Complex (MHC) proteins are cell surface molecules that bind and present peptide antigens to T lymphocytes, playing a crucial role in initiating adaptive immune responses. MHC Class I presents intracellular antigens to CD8+ T cells, while MHC Class II presents extracellular antigens to CD4+ T cells. In cancer, MHC molecules present tumor-associated antigens, enabling T-cell recognition and destruction of tumor cells. Dysregulation of MHC expression or antigen processing is a common mechanism of immune evasion in cancer, making MHC a key target for immunotherapy.

Other names

Human Leukocyte Antigen (HLA)Antigen Presentation MoleculesMHC Class IMHC Class II

Enhancing or restoring antigen presentation pathways, blocking immune checkpoints to reinvigorate T-cell responses against tumor cells presenting tumor antigens via MHC, engineering T-cells to recognize tumor antigen-MHC complexes.