Major Histocompatibility Complex Class I (HLA-B7) (HLA-B7)

HLA-B7 is a specific allele of the human MHC class I molecules, which are cell surface proteins found on all nucleated cells. These molecules play a central role in adaptive immunity by presenting intracellularly derived antigenic peptides to cytotoxic CD8+ T cells. HLA-B7 presents endogenous peptides to CD8+ T cells, triggering apoptosis in infected or abnormal cells. It is highly polymorphic, affecting peptide binding specificity and immune response diversity. HLA-B7 typing is critical for organ transplantation compatibility assessments and is associated with certain diseases like type 1 diabetes.

Other names

Human Leukocyte Antigen B7MHC Class I HLA-B7

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