Target intelligence / Profile preview

Manganese Ion (Hepatobiliary Uptake) (None)

Target: None
Molecular classification: Ion, Transporter substrate

Overview

Manganese (Mn) is an essential trace element actively transported into hepatocytes (liver cells), where it is processed and eventually excreted into bile. The liver plays a central role in regulating whole-body manganese homeostasis. Manganese-based compounds are used as contrast agents for MRI imaging due to their paramagnetic properties. Excess accumulation can lead to toxicity affecting neurological function.

Other names: Mn2+ (Hepatobiliary Uptake)Hepatic Manganese TransportManganese Chloride Tetrahydrate uptake

Mechanism of action

Hepatic uptake for contrast enhancement in MRI; competition with other divalent metals for uptake.

Biological functions

Micronutrient transportEnzyme cofactorHepatobiliary transportHomeostasis

Disease associations

Manganese deficiencyManganese toxicityLiver diseaseNeurological disorders (related to Mn dysregulation)

Safety considerations

Manganese toxicity (neurotoxicity)Potential interactions with other divalent metalsHepatic overload

Interacting drugs

Manganese chloride tetrahydrate

1 more in the full profile.

Biomarkers

Manganese blood levelsManganese concentration in liver tissue

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