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Mannosidase, beta A, lysosomal-like pseudogene
- Molecular classification
- Pseudogene, Non-coding DNA, Related to enzyme family of glycoside hydrolases (through homology to MANBA)
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Overview
Mannosidase, beta A, lysosomal-like pseudogene (ENSG00000224207) is a **pseudogene** found in the human genome. Pseudogenes are nonfunctional DNA segments that resemble protein-coding genes but do not produce functional proteins. This sequence shows homology to the MANBA gene, which encodes lysosomal beta-mannosidase, an important enzyme in glycoprotein metabolism. Pseudogenes typically arise from gene duplication or retrotransposition events, and though usually inactive, in some cases may have regulatory roles or be transcribed into non-coding RNA. This pseudogene is not a pharmacological target, does not contribute directly to disease phenotypes, and has no role in therapy or drug development. The *functional* lysosomal beta-mannosidase (MANBA, Entrez Gene: 4127) is a well-studied enzyme and *therapeutic target* in lysosomal storage disorders like beta-mannosidosis. The pseudogene is only related by sequence homology and does not substitute for or participate in the roles associated with the functional gene. If a structured, druggable target is wanted, you should search for "Mannosidase beta (MANBA)" rather than this pseudogene.
- Other names
- Lysosomal beta-mannosidase pseudogeneBeta-mannosidase, lysosomal-like pseudogene
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Mechanism of action
None
03
Biological functions
No established active biological functionMay be transcribed at low levelsIn rare cases, pseudogene transcripts regulate related genes, but most are nonfunctional
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Disease associations
No direct disease role; however, confusion may arise in genetic studies owing to sequence similarity with the functional MANBA genePseudogenes can complicate molecular analyses, e.g., PCR amplification bias
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Safety considerations
Not applicable
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