Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2)

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) is a Golgi enzyme vital for trimming alpha-1,2-linked mannose residues from N-glycans, producing structures required for proper glycoprotein maturation[1][2][5]. It belongs to the glycoside hydrolase family 47 and plays a central role in posttranslational protein modification and glycan quality control within the secretory pathway. Its function is implicated in diverse biological processes, including anti-inflammatory responses (where its expression can be downregulated by TNFα and restored by PPARγ agonists), viral pathogenesis (with increased expression during hepatitis B infection), and cellular adaptation to tissue injury[1][3]. Mutations or disruption of MAN1A2 lead to altered glycan profiles and are linked to rare congenital disorders of glycosylation. The enzyme is also of considerable interest in biotechnology, where manipulation of MAN1A2 (alongside MAN1A1 and MAN1B1) enables the production of recombinant proteins with defined high-mannose glycosylation patterns[3][1][5].

Other names

MAN1A2MAN1BAlpha-1,2-mannosidase IBProcessing alpha-1,2-mannosidase IBmannosyl-oligosaccharide 1,2-alpha-mannosidase IBMannosidase alpha class 1A member 2MA1A2_HUMAN

Modulation of glycoprotein maturation by altering N-glycan processing. Anti-inflammatory action via glycan remodeling (for PPARγ agonists).