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MAPK6 divergent transcript (MAPK6-DT), long noncoding RNA MAPK6 (lncMAPK6) (MAPK6-DT)
- Target
- MAPK6-DT
- Molecular classification
- Long noncoding RNA (lncRNA), Divergent transcript
01
Overview
MAPK6 divergent transcript (MAPK6-DT), also known as lncMAPK6, is a long noncoding RNA that originates from the divergent promoter region upstream of the MAPK6 gene. It is overexpressed in liver cancer and plays a key role in promoting the self-renewal of liver tumor-initiating cells and tumor propagation. Mechanistically, lncMAPK6 interacts with the MAPK6 promoter, recruits RNA polymerase II, and activates MAPK6 transcription, thereby driving MAPK signaling and contributing to oncogenic processes in the liver. Its overexpression is linked to poorer prognosis in liver cancer, highlighting its potential as both a biomarker and a therapeutic target, though no direct targeting agents are yet described.
- Other names
- lncMAPK6MAPK6-DTMAPK6 divergent transcript
02
Biological functions
Transcriptional regulationRegulation of signal transductionPromotion of liver tumor initiation cell (TIC) self-renewalTumor propagationCell proliferation
03
Disease associations
Cancer (specifically liver cancer, hepatocellular carcinoma)
04
Biomarkers
Overexpression of MAPK6-DT (lncMAPK6) is associated with liver tumorigenesis and may serve as a biomarker for liver cancer progression or TIC enrichment
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