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Marek's disease virus phosphoprotein pp38 (commonly used as the canonical antigen name; other specific MDV antigens include Meq oncoprotein and major capsid glycoproteins) (pp38, Meq)

Target
pp38, Meq
Molecular classification
Other (viral antigen), Oncoprotein (for Meq), Phosphoprotein (for pp38), Viral glycoprotein (for gC)
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Overview

Marek's disease virus antigens are a group of viral proteins expressed by Gallid alphaherpesvirus 2 (Marek's disease virus, MDV), including immunodominant phosphoproteins (such as pp38), oncoproteins (Meq), and viral glycoproteins (such as glycoprotein C). These antigens are critical for pathogenesis, immune response, and serve as key targets for vaccine development, serological diagnosis, and molecular monitoring of infection and virulence in poultry. They are not classical therapeutic targets but are essential biomarkers and immunological targets for disease control and poultry health management. In summary, "Marek's disease virus antigen" is too vague and covers multiple MDV proteins with distinct roles; for structured data, use the specific antigen’s name (e.g., "Marek’s disease virus phosphoprotein pp38" or "Marek’s disease virus Meq oncoprotein").

Other names
MDV antigenGallid alphaherpesvirus 2 antigenMDV pp38MDV MeqMDV glycoprotein CMDV gC
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Mechanism of action

Vaccine-induced immune response: live-attenuated or recombinant vaccines contain or express MDV antigens to induce protective immunity in chickens; Serological detection: antibodies bind antigens for lab diagnosis

03

Biological functions

Immune response (major immunogenic determinants during infection and vaccination)Oncogenesis (Meq)Virus replication and transformation (pp38, Meq)
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Disease associations

Infection (Marek’s disease, an oncogenic/neoplastic disease of poultry)Cancer (Meq—viral oncogenesis)
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Safety considerations

Vaccine escape and evolving virulence: new MDV antigenic variants can break vaccine-induced immunityTumor induction: Meq protein and other viral antigens are directly implicated in lymphomagenesis in chickens
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Biomarkers

pp38 antigen (used for diagnosis and transformation association in tissues)Meq (marker of virulence and pathogenicity)MDV DNA/protein detection is used for disease monitoring

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