MAS related GPR family member X12, pseudogene (MRGPRX12P)

MRGPRX12P (MAS related GPR family member X12, pseudogene) is a non-protein coding pseudogene related to the MAS-related G protein-coupled receptor X (MRGPRX) family, specifically associated with the "X2" member of this subfamily. It does not produce a functional protein and is not considered an active molecule for therapeutic intervention. Its name reflects its similarity to functional receptors such as MAS-related GPR family member X2 (MRGPRX2), which is a primate-specific orphan GPCR present on sensory neurons and immune cells and is actively researched for its role in pain, itching, inflammation, and pseudo-allergic drug reactions[1][2][4][5][8]. However, MRGPRX12P itself has no known function, disease involvement, or drug targeting relevance. For structured data extraction: - The only entries that correspond to an actual therapeutic target from this gene family are the true protein-coding receptors (MRGPRX1, MRGPRX2, MRGPRX3, MRGPRX4)[2][5][8], not this pseudogene. - Any references to therapeutic, biological, or pharmacological relevance should be omitted for MRGPRX12P. - If the intent is to target MAS related GPR family member X2 (MRGPRX2), that is a separate and functional receptor with extensive roles described in the literature, including mast cell degranulation, allergy, pain, itch, and interaction with several drugs and peptide ligands[2][4][5][8]. - For drug target/literature mining, ensure not to conflate "MRGPRX12P" with "MRGPRX2."

Other names

MAS related GPR family member X2 pseudogeneMAS-related GPR, member X2 pseudogeneMRGPRX12P