Mast cell surface protein (individual names include "Fc epsilon RI", "KIT receptor", "CD98hc", "Siglec-8", "MRGPRX2", etc., but no single canonical name exists for the group) (None for the group; individual abbreviations include FcεRI, KIT, CD98hc, etc.)

Mast cell surface proteins represent a heterogeneous group of membrane-bound molecules central to mast cell biology. They include receptors such as Fc epsilon RI (high-affinity IgE receptor) critical for allergic responses, KIT (CD117) vital for mast cell growth and survival, Siglec-8 associated with inhibition and depletion, CD98hc involved in cell adhesion and proliferation, and others. These proteins serve roles in immune surveillance, allergic inflammation, cardiovascular and bone homeostasis, and can be dysregulated in disorders such as mastocytosis, allergy, and cancers. Drugs targeting select mast cell surface proteins have shown efficacy in treating mast cell-driven diseases, but the broad distribution of many markers also poses safety and specificity challenges[2][4][6][7][5][3][1].

Other names

Mast cell membrane proteinsMast cell surface markersMast cell receptors (includes Fc epsilon RI, KIT, Siglec-8, MRGPRX2)

Inhibition of receptor tyrosine kinases (KIT inhibitors); Antibody-mediated depletion/blockade (Siglec-8, CD33); Inhibition of Fc epsilon RI/IgE-mediated activation (experimental antisense oligonucleotides); Inhibition/blockade of MRGPRX2 receptor signaling