Matrix metallopeptidase 2 (MMP2) messenger RNA 3' untranslated region (MMP2 mRNA 3'UTR)

The Matrix metallopeptidase 2 (MMP2) messenger RNA 3' untranslated region (3'UTR) is a critical regulatory segment of the MMP2 transcript that governs the stability and translation efficiency of the encoded gelatinase A enzyme (Source: PubMed, PMID: 25663484). This region contains multiple binding sites for microRNAs (miRNAs), such as the miR-29 family, which act as endogenous suppressors of MMP2 expression (Source: NIH, PMC3047131). In various pathological states, particularly oncology, the dysregulation of these regulatory interactions leads to the overexpression of MMP2, facilitating extracellular matrix degradation, tumor invasion, and metastasis (Source: Wikipedia, Matrix metalloproteinase-2). Consequently, the MMP2 mRNA 3'UTR has emerged as a therapeutic target for RNA-based interventions, including miRNA mimics and antisense oligonucleotides (ASOs), designed to silence MMP2 production (Source: PubMed, PMID: 28810355). By specifically targeting the 3'UTR, these therapies aim to restore normal proteolytic balance and inhibit the progression of invasive diseases like cancer and tissue fibrosis (Source: PubChem, MMP2).

Other names

MMP-2 3'UTRMatrix metalloproteinase-2 3'UTR72 kDa type IV collagenase mRNA 3'UTRGelatinase A mRNA 3'UTRMMP2 3-prime untranslated region

Binding of antisense oligonucleotides or microRNA mimics to the 3'UTR sequence leads to mRNA degradation or translational repression, thereby reducing the production of the MMP2 enzyme.