Melanoma antigen family A, 10 pseudogene

Melanoma antigen family A, 10 pseudogene (ENSG00000270794, also known as LOC100420324 or MAGEA10P) is a non-protein-coding member of the MAGEA gene family, classified as a pseudogene. The MAGEA family is best known for encoding cancer/testis antigens involved in oncogenesis and immune response, but pseudogenes like MAGEA10P do not produce functional proteins[5]. Some MAGEA pseudogenes may act as regulatory RNAs, potentially influencing cancer development or serving as miRNA decoys, but they are not considered direct therapeutic targets and are not currently targeted by drugs or immunotherapies[5].\n\nThere are functional MAGEA genes (e.g., MAGEA4, MAGEA10) that are under study as immunotherapy targets in cancer, but ENSG00000270794 is not one of them, as it is explicitly annotated as a pseudogene and does not code for a protein[1][3][4][5]. The nomenclature and roles of MAGEA pseudogenes are an area of ongoing molecular research, and while some literature references roles in gene regulation, these are largely indirect and not associated with direct molecular targeting by therapeutics[5].

Other names

LOC100420324MAGEA10Pmelanoma antigen family A, 10 pseudogene