Membrane estrogen receptor (putative, ERx) (ERx)

ERx is a putative membrane estrogen receptor identified via its associated gene transcription signature that is induced by estradiol independently of the classical nuclear and membrane estrogen receptors ERα, ERβ, and GPER. It was characterized using a membrane-impermeable estradiol conjugate (E2-BSA), in studies where classic ER antagonists and GPER antagonists were used to dissect out independent pathways. Little is known about the molecular identity, structure, or biological roles of ERx. There is no evidence it is targeted by approved drugs or is a validated therapeutic target. Much of the literature using "ERX" actually refers to ERX-11, a small molecule modulator of ERα function, which is unrelated to ERx as a distinct receptor.

Other names

ER-XMembrane estrogen receptormERERx gene signature

Estradiol-induced gene transcription through a non-ERα/ERβ/GPER pathway