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Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (PALS1)
- Target
- PALS1
- Molecular classification
- Scaffold protein, MAGUK (Membrane-associated guanylate kinase) family, p55 subfamily, PDZ domain-containing protein
01
Overview
Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (PALS1), encoded by the MPP5 gene, is a scaffold protein of the MAGUK family critical to the assembly and maintenance of cell junctions in epithelial tissues. It contains PDZ, SH3, GUK, and L27 domains, allowing interaction with tight junction proteins such as PATJ and Crumbs homologues, thereby forming complexes that orchestrate cell polarity and tight junction integrity. PALS1 regulates apical-basal polarization, junctional protein trafficking, and neural/retinal development. Dysfunction or reduced expression is linked to developmental abnormalities, such as retinal degeneration, and general disruption of epithelial architecture. It does not have established direct roles in drug targeting or serve as a primary biomarker, but participates in pathways relevant for tissue organization and cancer suppression via MAGUK family function.
- Other names
- PALS1MPP5Protein associated with LIN7 1MAGUK p55 family memberMembrane palmitoylated protein 5Stardust (Drosophila homologue)
02
Mechanism of action
Not applicable; no drugs target PALS1 directly.
03
Biological functions
Establishment and maintenance of epithelial cell polarityTight junction biogenesisAdherens junction biogenesisOrganization of apical-basal membrane domainsCell junction organizationRegulation of myelinating Schwann cellsCerebellar development and neuronal progenitor cell survivalRetinal development and maintenanceTrafficking and localization of junctional proteins
04
Disease associations
Retinal degeneration (mutation in orthologous gene associated with impaired vision)Neurodevelopmental processesArachnoid cysts (locus association)Cancer (tumor suppression as a general property of MAGUK family)
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