Messenger RNA of tumor suppressor genes (TSG mRNA) (TSG mRNA)

Messenger RNA (mRNA) of tumor suppressor genes (TSGs) represents a therapeutic class focused on restoring the function of proteins that inhibit tumor growth and maintain genomic stability (Sahin et al., 2014). In many malignancies, TSGs such as TP53 or PTEN are inactivated by mutations, leading to uncontrolled proliferation and resistance to apoptosis (Khoo et al., 2014). mRNA replacement therapy involves the delivery of synthetic, modified mRNA encoding these functional proteins directly into cancer cells (Islam et al., 2018). Once inside, the mRNA is translated into functional tumor suppressor proteins that can reinstate normal cell cycle control or trigger programmed cell death. This approach is particularly valuable for targeting "undruggable" loss-of-function mutations where traditional small molecules are ineffective. However, clinical success depends on efficient delivery systems like lipid nanoparticles and managing the transient nature of mRNA-mediated protein expression (Weng et al., 2020).

Other names

Tumor suppressor transcriptsmRNA replacement therapy targetsTumor suppressor gene mRNA

Restoration of functional tumor suppressor protein expression through the delivery of exogenous, synthetic messenger RNA, which utilizes the host cell's translational machinery to bypass endogenous genetic mutations or deletions (Sahin et al., 2014; Pardi et al., 2018).