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Metallothionein 1D, pseudogene (MT1DP)
- Target
- MT1DP
- Molecular classification
- Other (Long non-coding RNA), Metallothionein family pseudogene
01
Overview
Metallothionein 1D, pseudogene (MT1DP) is a non-protein-coding member of the metallothionein gene family, present in the human genome and transcribed as a long non-coding RNA. Unlike protein-coding MT isoforms, MT1DP is specifically induced in hepatocytes in response to cadmium stress, where it promotes cytotoxicity and apoptosis via interactions with RhoC protein and MT1H through a ceRNA network. MT1DP has been described as having pro-apoptotic activity in cancer cells and is involved in modulating the cellular response to heavy metal exposure, especially cadmium. It is one of several metallothionein pseudogenes encoded in the human genome, with no direct ortholog in mouse. MT1DP is relevant in research for its role in cellular stress responses, but does not represent a classical therapeutic target or protein receptor.
- Other names
- Putative metallothionein MT1DPMT1DPMTM
02
Mechanism of action
Not applicable. MT1DP is not a classical drug target; mechanisms of action described involve its function as a lncRNA modulating protein partners and cellular signaling
03
Biological functions
Cellular response to cadmium (CAD) stressRegulation of apoptosisCompeting endogenous RNA (ceRNA) activityModulation of cell signaling via RhoC/CCN1/2-AKT pathway
04
Disease associations
Cancer (reported as having tumor suppressor activity in liver cancer)Metal toxicity response (cadmium toxicity)Possible roles in immune modulation are inferred from metallothionein family's involvement but unproven for MT1DP directly
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