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Methylation Pathway via S-adenosylmethionine (SAM) (SAM Methylation Pathway)
- Target
- SAM Methylation Pathway
- Molecular classification
- Metabolic Pathway, Enzyme-Mediated Process, Epigenetic Modification Pathway
01
Overview
The methylation pathway via S-adenosylmethionine (SAM) is a fundamental cellular process where SAM acts as the primary methyl group donor for methylation reactions. It is essential for gene regulation, epigenetic modification, neurotransmitter synthesis, detoxification, and overall metabolic function. Disturbances in this pathway are linked to various diseases, and modulation has been explored therapeutically.
- Other names
- S-adenosylmethionine PathwaySAMe PathwayTransmethylation Pathway
02
Mechanism of action
SAM acts as a methyl donor, facilitating the transfer of methyl groups to various substrates. Modulation of enzymes involved in the pathway affects overall methylation capacity.
03
Biological functions
Gene regulationEpigenetic modificationNeurotransmitter synthesisDetoxificationMetabolic functionCell growth/divisionNucleic acid modificationProtein modification
04
Disease associations
Neuropsychiatric disordersNeurodegenerative diseasesMetabolic syndromeObesity
05
Safety considerations
Potential for adverse effects with SAMe supplementationInhibition of transmethylation due to SAH accumulationDisturbances in homocysteine metabolism
06
Interacting drugs
SAMe (S-adenosylmethionine)
1 more in the full profile.
07
Biomarkers
SAM levelsSAH levelsHomocysteine levelsSAM/SAH ratio
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