Microbial Enzymes (Thiol-Containing)

Microbial enzymes that are thiol-containing encompass a diverse group of enzymes found in microorganisms (bacteria, fungi, protozoa) that possess one or more thiol (-SH) groups, typically contributed by cysteine residues. These thiol groups are critical for the enzyme's catalytic activity, redox regulation, and structural stability. Thiol-containing microbial enzymes play essential roles in cellular metabolism, antioxidant defense mechanisms, and adaptation to environmental stress. Examples include thioredoxin reductase, glutaredoxin, and β C-S lyases. Low-molecular-weight thiols like glutathione, mycothiol, and bacillithiol act as cofactors. These enzymes are vital for survival under oxidative stress and can serve as potential drug targets.

Inhibition of enzymatic activity via modification of thiol group; disruption of redox balance