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Microbial Metabolite (Gut-Derived)
- Molecular classification
- Small molecule, Metabolite, Short-chain fatty acid (SCFA), Bile acid derivative, Amino acid derivative
01
Overview
Microbial metabolites (gut-derived) are small molecules produced by the gut microbiota. These metabolites are either direct products of microbial metabolism or result from microbial modification of host or dietary compounds. They serve as crucial mediators in host-microbe interactions and play significant roles in maintaining health and contributing to disease. Examples include SCFAs, bile acid derivatives, and amino acid derivatives. They influence various physiological processes, and altered production is associated with several diseases.
- Other names
- Gut-derived microbial metaboliteMicrobiota-derived metaboliteBacterial metabolite (gut)Gut microbiome metabolite
02
Biological functions
Immune modulationEnergy sourceSignaling moleculeRegulation of intestinal barrier integrityModulation of metabolic homeostasisGut-brain communication
03
Disease associations
Neurodegenerative diseaseMetabolic syndromeObesityInflammatory bowel diseaseColorectal cancerAutism spectrum disorders
04
Safety considerations
Dysbiosis-induced changesPotential for toxicity depending on metabolite and concentrationIndividual variability in response
05
Biomarkers
SCFA levelsSecondary bile acid levelsTMAO levelsIndole levels
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