MicroRNA 125b-3p (miR-125b-3p) (miR-125b-3p)

MicroRNA 125b-3p (formerly designated as miRNA-125b*) is a small non-coding RNA molecule that functions as a key regulator of gene expression at the post-transcriptional level. It is derived from the precursor microRNA-125b hairpins and was historically referred to as the passenger strand, though it is now recognized as a functional molecule in its own right (miRBase: MI0000469). miR-125b-3p works by binding to the 3' untranslated regions (UTRs) of target messenger RNAs, leading to translational inhibition or mRNA degradation (PubMed: 23536710). This microRNA is involved in diverse biological processes, including the regulation of apoptosis, cell differentiation, and the innate immune response. In clinical contexts, miR-125b-3p is frequently dysregulated in diseases such as breast cancer, hepatocellular carcinoma, and neurodegenerative disorders like Alzheimer's disease (PubMed: 30613214, PubMed: 24508415). Therapeutic strategies targeting miR-125b-3p involve the use of antisense oligonucleotides (antagomirs) to silence its activity in overexpressed states or synthetic mimics to restore its function in deficient states. However, the development of miR-125b-3p-targeted therapies faces significant challenges, including ensuring tissue-specific delivery and minimizing off-target effects on the complex regulatory networks it governs.

Other names

miRNA-125b*hsa-miR-125b-3pmiR-125b passenger strandmiR-125b-star

Modulation of gene expression through antisense-mediated sequestration of the microRNA (antagomirs) to prevent it from binding its target mRNAs, or through the introduction of synthetic miRNA mimics to restore translational repression of target genes (PubMed: 23536710).