MicroRNA 17-92 cluster host gene (MIR17HG) (MIR17HG)

The MicroRNA 17-92 cluster host gene (MIR17HG), also known as the miR-17-92 cluster primary transcript or Oncomir-1, is a polycistronic non-coding RNA located on human chromosome 13 (He et al., 2005, Nature). It serves as the precursor for six mature microRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92a-1, which collectively regulate key cellular pathways including the cell cycle, apoptosis, and proliferation (Mogilyansky & Rigoutsos, 2013, Cell Death & Disease). This cluster is frequently overexpressed in various cancers, such as B-cell lymphomas and lung cancer, where it functions as an oncogene by targeting tumor suppressors like PTEN and BIM (Concepcion et al., 2012, Biomolecular Concepts). Beyond oncology, the cluster is involved in developmental disorders, as germline deletions lead to Feingold syndrome, and it has been implicated in the progression of polycystic kidney disease (NIH, Genetic and Rare Diseases Information Center). Therapeutic interventions targeting MIR17HG primarily involve antisense oligonucleotides (ASOs) designed to sequester mature miRNAs or interfere with the processing of the primary transcript. Candidates like RGLS4326 (RGL-112) are undergoing clinical evaluation for polycystic kidney disease, demonstrating the therapeutic potential of modulating this cluster (Regulus Therapeutics, 2024). The complex regulation of this transcript makes it a significant focal point for both diagnostic and therapeutic advancements in precision medicine.

Other names

C13orf25Oncomir-1miR-17-92 clusterMIR17-92MIR17 host genePrimary miR-17-92 transcript

Antisense-mediated sequestration of mature miRNAs, inhibition of primary transcript processing by Drosha/Dicer complexes, or transcriptional silencing of the host gene.