MicroRNA 199b-5p (miR-199b-5p) (miR-199b-5p)

MicroRNA 199b-5p (miR-199b-5p) is a mature microRNA derived from the MIR199B gene that serves as a critical post-transcriptional regulator of gene expression [2, 16]. It functions by binding to the 3' untranslated regions (3' UTR) of various target mRNAs, including HER2, DDR1, ALK1, and Dyrk1a, thereby inducing their degradation or inhibiting their translation [1, 3, 4, 18]. In oncology, miR-199b-5p predominantly acts as a tumor suppressor in cancers such as breast cancer and medulloblastoma, where its downregulation is associated with increased tumor growth, metastasis, and poor clinical outcomes [2, 4, 13]. However, its role is context-dependent, as it has been observed to function as an oncogenic driver in gastric cancer by promoting cell proliferation and epithelial-to-mesenchymal transition [6, 7]. Beyond its role in cancer, miR-199b-5p is a key mediator of pathological cardiac remodeling and hypertrophy, where its upregulation activates the calcineurin/NFAT signaling pathway [18, 19]. Therapeutic approaches targeting miR-199b-5p include the use of miRNA mimics to restore its suppressive activity in tumors and antagomirs to mitigate its harmful effects in cardiovascular diseases [13, 18, 22].

Other names

hsa-miR-199b-5pMIR199BMIRN199BMicroRNA 199b

Post-transcriptional gene silencing via binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to translational repression or mRNA degradation.