MicroRNA 24 (miR-24) (miR-24)

MicroRNA 24 (miR-24) is a highly conserved small non-coding RNA that regulates gene expression post-transcriptionally by binding to the 3' untranslated regions of target mRNAs (Srivastava et al., 2011, PMID: 21163921). It is encoded by two distinct genetic clusters, miR-23a~27a~24-2 and miR-23b~27b~24-1, and is widely expressed across various tissues (Xiang et al., 2014, PMID: 25242301). miR-24 plays a critical role in biological processes such as cell proliferation, apoptosis, and differentiation, particularly in hematopoietic and cardiac lineages (Fiedler et al., 2011, PMID: 21636814). In oncology, miR-24 acts as a "dual-function" microRNA, serving as either an oncogene or a tumor suppressor depending on the specific cellular context and target availability (Giglio et al., 2013, PMID: 23933435). In cardiovascular disease, it is a key regulator of angiogenesis and fibrosis, with its downregulation often observed following myocardial infarction (Fiedler et al., 2011, PMID: 21636814). Therapeutic targeting of miR-24 is currently being explored, with the locked nucleic acid (LNA)-based antagomir MRG-110 entering clinical trials for conditions involving impaired vascularization (Gallant-Behm et al., 2018, PMID: 30135519). This molecule represents a promising target for precision medicine due to its ability to simultaneously modulate multiple pathways involved in tissue repair and disease progression.

Other names

miR-24-3phsa-miR-24MIR24-1MIR24-2MicroRNA 24-1MicroRNA 24-2

Post-transcriptional gene silencing through sequence-specific binding to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs), leading to translational inhibition or mRNA degradation (Srivastava et al., 2011, PMID: 21163921).