MicroRNA-29 target messenger RNAs (miR-29 targets) (miR-29 targets)

MicroRNA-29 (miR-29) target messenger RNAs (mRNAs) are a collection of transcripts that possess complementary sequences to the miR-29 seed region, primarily within their 3' untranslated regions (UTRs). The miR-29 family, which includes miR-29a, miR-29b, and miR-29c, serves as a pivotal regulator of the extracellular matrix (ECM) by suppressing the translation and stability of mRNAs encoding various collagens (e.g., COL1A1, COL3A1), elastin, and fibrillin (Maurer et al., 2010, Journal of Clinical Investigation). In addition to their role in fibrosis, these target mRNAs encompass genes involved in cell survival (e.g., MCL1) and DNA methylation (e.g., DNMT3A and DNMT3B), linking them to oncogenesis and cardiovascular remodeling (Deng et al., 2017, Oncotarget). Therapeutic intervention typically utilizes miR-29 mimics, such as Remlarsen (MRG-201), to replenish miR-29 levels in conditions where the microRNA is pathologically downregulated, such as in pulmonary fibrosis or systemic sclerosis (Gallant-Behm et al., 2019, JCI Insight). By specifically binding to these seed-matched sites, the mimics facilitate the degradation of profibrotic or pro-survival transcripts, thereby mitigating disease progression. These targets are also relevant in oncology, where miR-29 downregulation leads to the overexpression of oncogenic targets like TCL1 in chronic lymphocytic leukemia (Pekarsky et al., 2006, Cancer Research). However, the broad regulatory network of miR-29 necessitates careful monitoring for off-target effects and potential immune activation associated with oligonucleotide delivery (Montgomery et al., 2014, Journal of Cardiovascular Pharmacology).

Other names

miR-29 seed-matched transcriptsmiR-29 regulated mRNAsMicroRNA-29 targets

MicroRNA mimicry leading to RNA-induced silencing complex (RISC)-mediated degradation or translational repression of target mRNAs.