MicroRNA 548aq-3p (miR-548aq-3p) (miR-548aq-3p)

MicroRNA 548aq-3p (miR-548aq-3p) is a small non-coding RNA molecule that regulates gene expression post-transcriptionally by binding to the 3' untranslated region (UTR) of target mRNAs [2, 5]. It has emerged as a significant therapeutic target in oncology and cardiovascular medicine [2, 3, 5]. In epithelial ovarian cancer, miR-548aq-3p is transported via exosomes and promotes cisplatin resistance by downregulating the Mediator Complex Subunit 12 (MED12), thereby enhancing cell survival and inhibiting apoptosis [2, 3]. In the context of coronary artery disease, it acts as an anti-angiogenic factor that inhibits the tube formation and migration of endothelial colony-forming cells (ECFCs) [5, 11]. Suppression of miR-548aq-3p, such as through far infrared radiation (FIR) therapy, has been shown to improve vascular repair mechanisms and serves as a biomarker for FIR responsiveness [5, 9]. Additionally, miR-548aq-3p is implicated in intervertebral disk degeneration through its involvement in autophagy-related pathways [10]. Research suggests that inhibiting this miRNA could enhance chemotherapy sensitivity in cancer or improve vascular outcomes in ischemic diseases [2, 5, 6].

Other names

hsa-miR-548aq-3pMIR548AQMIMAT0022264MicroRNA 548aq

Post-transcriptional gene silencing of target mRNAs, including MED12, through sequence-specific binding to the 3' untranslated region (UTR) [2, 3, 5].