MicroRNA 891a (miR-891a) (miR-891a)

MicroRNA 891a (miR-891a) is a small, endogenous non-coding RNA molecule that plays a critical role in the post-transcriptional regulation of gene expression. Located on the X chromosome at the Xq27.3 locus, it belongs to a cluster of microRNAs that modulate various physiological and pathological processes. miR-891a functions by binding to the 3' untranslated regions (UTRs) of specific target mRNAs, leading to their degradation or translational repression. In the context of oncology, miR-891a exhibits a dual role, acting as an oncogene in non-small cell lung cancer and colorectal cancer by promoting cell proliferation and invasion through the targeting of HOXA5 and CPEB1. Conversely, in hormone receptor-positive breast cancer, it has been identified as a tumor suppressor that inhibits metastasis by targeting ADAM10. Beyond cancer, miR-891a is involved in viral pathogenesis, such as promoting angiogenesis in Kaposi's sarcoma by activating the NF-κB signaling pathway through the inhibition of IκBα. Its distinct expression patterns in diseased tissues and biofluids make it a promising candidate for diagnostic and prognostic biomarkers. Furthermore, miR-891a is being explored as a potential therapeutic target, with experimental inhibitors like pHLIP-PNA-antimiR-891a and natural modulators like trans-chalcone being investigated for their ability to regulate its activity in disease states.

Other names

miR-891a-5pmiR-891a-3pMIR891Ahsa-miR-891a

Binds to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs) to inhibit translation or promote mRNA degradation, thereby regulating the expression of genes such as HOXA5, ADAM10, CPEB1, and IκBα.