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Target intelligence / Profile preview
Microtubule (specifically β-tubulin within assembled microtubules) (MT)
- Target
- MT
- Molecular classification
- Cytoskeletal protein, Structural protein
01
Overview
Microtubules are essential components of the cytoskeleton involved in cell division, intracellular transport, and maintenance of cell shape. Paclitaxel and docetaxel bind to β-tubulin within assembled microtubules, stabilizing them and preventing depolymerization. This leads to mitotic arrest and apoptosis, making them effective anticancer agents.
- Other names
- TubulinAssembled microtubulesβ-tubulin
02
Mechanism of action
Prevents microtubule depolymerization, leading to microtubule stabilization, mitotic arrest at G2/M phase, and induction of apoptosis.
03
Biological functions
Cell divisionIntracellular transportMaintenance of cell shapeMitosisChromosome segregation
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionNeuropathyHypersensitivity reactionsFluid retention (especially with docetaxel)
06
Interacting drugs
Paclitaxel
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