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Microtubule assembly (colchicine-binding site)
- Molecular classification
- Tubulin, Structural protein
01
Overview
The colchicine-binding site is a specific region on tubulin, the building block of microtubules. Binding of colchicine or other inhibitors to this site prevents proper polymerization of tubulin dimers into microtubules, disrupting normal microtubule dynamics and inhibiting cell division. This mechanism is exploited in cancer chemotherapy.
02
Mechanism of action
Inhibition of microtubule polymerization by stabilizing a curved, non-polymerizable tubulin conformation.
03
Biological functions
Cell cycleMitosisIntracellular transportMaintenance of cell shapeChromosome segregation
04
Disease associations
Cancer
05
Safety considerations
Multidrug resistance (less susceptible than other antimitotics)General cytotoxicity due to disruption of cell division
06
Interacting drugs
Colchicine
1 more in the full profile.
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