Microtubule-associated protein 7 (MAP7) (MAP7)

Microtubule-associated protein 7 (MAP7), also known as E-MAP-115, is a 115 kDa protein that plays a pivotal role in the regulation of microtubule dynamics and intracellular transport (UniProt Q14244). It functions as a critical adapter that recruits kinesin-1 (KIF5B) to microtubules, thereby facilitating the movement of organelles and proteins essential for cell polarization and migration (Metivier et al., 2019, Nature Communications). In the context of oncology, MAP7 mRNA is frequently overexpressed in various malignancies, including gastric, colorectal, and breast cancers, where it is associated with poor prognosis and promotes tumor cell proliferation and invasion (PubMed: 30107480). Consequently, MAP7 mRNA has emerged as a promising therapeutic target, with experimental strategies utilizing small interfering RNAs (siRNAs) to downregulate its expression and inhibit oncogenic signaling pathways (PubMed: 33454154). Beyond its role in cancer, MAP7 is involved in the development of the nervous system, and its dysregulation may have implications for neurodegenerative or neurodevelopmental disorders (NCBI Gene ID: 9053). Targeting the mRNA of MAP7 offers a specific approach to disrupt the kinesin-microtubule interaction, which is often exploited by cancer cells to maintain their high metabolic and migratory demands.

Other names

E-MAP-115EnsconsinMAP-7RC1Epithelial microtubule-associated protein of 115 kDa

Antisense or RNA interference-mediated knockdown of MAP7 mRNA, leading to reduced protein levels and subsequent inhibition of kinesin-1-driven transport and microtubule-dependent cell processes.