Microtubule-associated protein 7 (MAP7) mRNA 3'-untranslated region (3'-UTR) (MAP7 mRNA 3'-UTR)

The Microtubule-associated protein 7 (MAP7) mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the messenger RNA encoding the MAP7 protein, also known as ensconsin. This region contains multiple binding sites for microRNAs (miRNAs) and RNA-binding proteins that modulate the stability and translation efficiency of the MAP7 transcript (Source: UniProt O60318). MAP7 itself is a key regulator of the microtubule cytoskeleton, functioning to stabilize microtubules and recruit kinesin-1 motors for intracellular transport (Source: PubMed: 29610382). In several malignancies, including colorectal and breast cancers, the MAP7 3'-UTR is a focal point for dysregulation; specifically, the loss of inhibitory miRNAs that normally bind this region leads to MAP7 overexpression, which promotes tumor cell invasion and metastasis (Source: PubMed: 30612335). Therapeutic approaches targeting the MAP7 mRNA 3'-UTR involve the use of miRNA mimics or antisense oligonucleotides (ASOs) designed to bind the 3'-UTR and reduce MAP7 protein levels, thereby inhibiting oncogenic progression (Source: PubMed: 31256145). As an RNA-based target, it offers a specific pathway for precision medicine in cancers where MAP7 is a driver of disease.

Other names

Ensconsin mRNA 3'-UTRE-MAP-115 mRNA 3'-UTRMAP-7 mRNA 3'-UTRMTAP7 mRNA 3'-UTR

MicroRNA-mediated silencing or antisense oligonucleotide-induced degradation of the MAP7 mRNA transcript via sequence-specific binding to the 3'-untranslated region.