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Target intelligence / Profile preview
Microtubule Function (Indirect Inhibition via Oxaliplatin)
- Molecular classification
- Other
01
Overview
Oxaliplatin is a platinum-based chemotherapy drug that primarily targets DNA, causing crosslinks and inhibiting replication. While it doesn't directly bind to tubulin or inhibit microtubule polymerization like classical microtubule-targeting agents (e.g., taxanes, vinca alkaloids), it can indirectly affect microtubule function by disrupting cellular processes such as nucleolar stress and impacting the expression/localization of proteins involved in mitotic spindle formation. This indirect effect contributes to its antitumor activity, particularly in colorectal cancer.
- Other names
- Oxaliplatin-induced microtubule disruptionOxaliplatin and cytoskeletonOxaliplatin effects on mitotic spindle
02
Mechanism of action
Indirect inhibition of microtubule function through DNA crosslinking and disruption of cellular processes required for proper spindle assembly during mitosis.
03
Biological functions
Cell cycleApoptosisMitosisIntracellular transport
04
Disease associations
Cancer
05
Safety considerations
Peripheral neuropathy (related to oxaliplatin)Myelosuppression (related to oxaliplatin)
06
Interacting drugs
Oxaliplatin
2 more in the full profile.
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