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MIR133A1 host gene (non-protein coding) (MIR133A1HG)
- Target
- MIR133A1HG
- Molecular classification
- Long non-coding RNA (lncRNA), Non-coding RNA
01
Overview
MIR133A1 host gene (MIR133A1HG) is a long non-coding RNA on human chromosome 18 that serves as the primary transcript (host gene) for the production of the muscle-specific microRNA miR-133a-1[3][4][6]. The host gene itself does not encode a protein and its specific functions—apart from giving rise to miR-133a-1—are not well characterized[6]. Diseases linked to MIR133A1HG primarily reflect the functions of its microRNA product, and include leukemias and inflammatory diseases[3]. MIR133A1HG is officially recognized as a lncRNA gene by gene databases[3][6]. There are no known direct drug interactions, mechanisms of action, biomarker roles, or specific safety/therapeutic considerations related to MIR133A1HG itself; most research focuses on miR-133a-1.
- Other names
- MIR1-2HGMIR1-2 host gene (non-protein coding)MIR133A1HGMIR133A1 host gene
02
Biological functions
Acts as host gene for production of microRNA miR-133a-1May be involved in post-transcriptional regulation of gene expression via the microRNA it hosts
03
Disease associations
LeukemiaInflammatory diseasePossible involvement in other diseases via regulation by miR-133a-1 (associated with cancer, diabetes, cardiovascular disease as reported for miR-133a-1 itself, but the lncRNA host gene’s role is not directly stated)
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