MIR22 host gene (non-protein coding) (MIR22HG)

MIR22 host gene (MIR22HG) is a long non-coding RNA (lncRNA) located on chromosome 17p13.3 that functions principally as a host gene for microRNA-22 (miR-22). Though it is not translated into a protein, MIR22HG plays important regulatory roles in gene expression, cellular proliferation, differentiation, apoptosis, and tumor suppression. In cancer biology, MIR22HG is widely recognized as a tumor suppressor: overexpression inhibits tumor cell viability, proliferation, migration, and invasion, while low MIR22HG expression is associated with cancer progression and poor prognosis in diseases such as hepatocellular carcinoma, breast cancer, and glioblastoma. It acts in part by generating the mature miR-22-3p and miR-22-5p microRNAs, by sponging additional miRNAs such as miR-629-5p, and by interacting with RNA-binding proteins like HuR to stabilize key tumor suppressor applications (such as LATS2) and modulate oncogenic pathways (such as Wnt/β-catenin and YAP1). Research on MIR22HG highlights its potential as a prognostic marker and a novel therapeutic target in oncology, although no drugs currently target MIR22HG directly.

Other names

MIR22HGC17orf91MGC14376DKFZp686O06159MIR22 host genelnc-TLCD2-1MIRN22hsa-mir-22miR-22

Inhibition or restoration of MIR22HG levels affects miR-22-3p/miR-22-5p levels, impacting downstream oncogenic pathways (e.g., Wnt/β-catenin, EMT, Notch, STAT3, HMGB1, LATS2/YAP1). Functions partly as a “molecular sponge” for miR-629-5p, regulating other targets. Tumor suppressor function by modulating progression, invasion, migration, and apoptosis pathways.