Mitochondrial membrane (Inner and Outer)

The mitochondrial membranes—comprising the inner mitochondrial membrane (IMM) and the outer mitochondrial membrane (OMM)—form the structural foundation of mitochondria, the cell’s primary site for ATP (energy) production. The IMM houses the electron transport chain and ATP synthase, driving oxidative phosphorylation and maintaining a strong membrane potential. The OMM is more permeable, hosting enzymes and proteins involved in signaling, metabolite exchange, and apoptosis regulation. Dysfunction in these membranes—by genetic mutation, chemical damage, or altered lipids—can cause or contribute to a wide range of diseases. Although singular proteins in these membranes are valid drug targets, the "mitochondrial membrane" as such is not considered a therapeutically targetable molecule but a compartment containing many distinct targets.

Other names

Inner mitochondrial membrane (IMM)Outer mitochondrial membrane (OMM)IMMOMMmitochondrial double membrane

Disruption of oxidative phosphorylation by inhibiting electron transport chain complexes; Altering mitochondrial permeability (induction or blockade); Modulation of apoptosis by affecting mitochondrial outer membrane permeabilization (MOMP)