Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 24 (MTND4P24)

MT-ND4 pseudogene 24 (MTND4P24) is classified as a pseudogene, specifically a nuclear pseudogene related to the mitochondrial gene MT-ND4, which normally encodes a subunit of complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial electron transport chain[2][4][6][8][10]. The pseudogene is located on the X chromosome and is non-functional; it does not produce a protein product and exhibits multiple mutations, including premature stop codons, that prevent it from encoding a functional enzyme[9][2][4][10]. MTND4P24 is not a therapeutic target, nor is it involved in established biological pathways or disease mechanisms itself. It is named after, but distinct from, the functional mitochondrial ND4 gene, which is well studied in contexts such as mitochondrial disorders and electron transport[1][3][5][7]. However, pseudogenes like MTND4P24 can sometimes complicate genomic studies or PCR amplification by yielding non-functional copies in nuclear DNA[9]. There is no evidence linking MTND4P24 to any drug interactions, clinical biomarkers, or safety concerns[2][4][6][8][10]. Note: If you were seeking information on the functional mitochondrial gene (MT-ND4) rather than the pseudogene, that is a critical distinction. The functional MT-ND4 gene encodes a core subunit of complex I and is relevant for mitochondrial energy metabolism and several diseases, but MTND4P24 is a non-functional pseudogene and is not a therapeutic target[2][4][6][8][10].

Other names

MTND4P24MT-ND4 pseudogene 24