Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 27 (MTND4P27)

MT-ND4 pseudogene 27 (MTND4P27) is a nuclear-encoded pseudogene similar in sequence to the mitochondrial MT-ND4 gene, which encodes a subunit of complex I in the mitochondrial electron transport chain[9]. MTND4P27 itself does not produce a functional protein: it is regarded as a non-translated genomic element, likely resulting from the migration of mitochondrial DNA sequences into the nuclear genome. Unlike MT-ND4, which is implicated in various mitochondrial diseases, there are no direct functions or clinical associations reported for MTND4P27. Its existence is primarily noted in genome annotation studies and mitochondrial genetics, where the presence of nuclear mitochondrial pseudogenes can complicate genetic analysis and interpretation[9]. If you need information for the functional MT-ND4 gene or protein, those are considered bona fide targets with established disease associations, biomarker utility, and mechanistic relevance[1][3][5][7][10]. If your query was intended for the active MT-ND4 gene rather than a specific pseudogene, please clarify. Otherwise, MTND4P27 is not a therapeutic target and should generally not be included as a drug development or biomarker entity.

Other names

MT-ND4 pseudogene 27MTND4P27mitochondrially encoded NADH dehydrogenase 4 pseudogene 27NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 27