Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway (MAPK pathway)
- Target
- MAPK pathway
- Molecular classification
- Signaling pathway, Kinase cascade
01
Overview
The mitogen-activated protein kinase (MAPK) signaling pathway is a highly conserved cascade of protein kinases that transmits extracellular signals to regulate a wide range of essential cellular processes, including proliferation, differentiation, apoptosis, stress responses, and immune defense. It operates through a multi-tiered kinase cascade: MAP3K, MAP2K, and MAPK. Major subfamilies include ERKs, JNKs, and p38. Dysregulation can lead to diseases including cancer or neurological disorders.
- Other names
- MAP kinase pathwayERK pathwayJNK pathwayp38 pathway
02
Mechanism of action
Inhibition of kinase activity at various nodes in the pathway.
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosisStress responseImmune responseCell cycle progression
04
Disease associations
CancerNeurological disordersInflammation
05
Safety considerations
Resistance developmentOff-target effectsPathway crosstalk
06
Interacting drugs
MEK inhibitors
1 more in the full profile.
07
Biomarkers
RAS mutationsRAF mutationsERK phosphorylation levelsJNK phosphorylation levelsp38 phosphorylation levels
Beyond the preview
Go deeper on Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway (MAPK pathway).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway (MAPK pathway).