Mon1 homolog A, secretory trafficking associated (Mon1a)

Mon1 homolog A (Mon1a) plays a critical role as a regulator of vesicle trafficking, acting predominantly in the secretory apparatus to facilitate movement of proteins and lipids from the endoplasmic reticulum (ER) to the Golgi and onward to the plasma membrane. Mon1a acts as part of the Mon1-Ccz1 complex, which functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Rab7, coordinating the transition from early to late endosomes and regulating organelle identity and autophagy. Disruption of Mon1a impairs the formation and movement of secretory vesicles, alters Golgi morphology, and may impact iron homeostasis. Known genetic mutations in Mon1a are associated with altered protein trafficking and specific diseases such as congenital diarrhea, but Mon1a itself is not a conventional therapeutic target. It is principally studied for basic mechanistic insights into membrane trafficking and organelle dynamics.

Other names

Mon1aMON1AMON1SAND1

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