Monoamine oxidase (bacterial)

Bacterial monoamine oxidase refers to a class of flavin-containing oxidative enzymes found in some bacterial species, which catalyze the breakdown of primary and secondary amines, including monoamines and polyamines, by oxidative deamination. While similar in broad enzymatic function to human MAO-A and MAO-B, bacterial MAOs are generally soluble (not membrane-bound), can display thermostability, and exhibit diverse substrate specificity. Structurally, they share a conserved flavin adenine dinucleotide (FAD)-binding site with eukaryotic MAOs, but vary in their sequence, substrate access, and active site architecture. Their physiological roles in bacteria are not fully understood but likely relate to nitrogen metabolism or catabolism of amine compounds. Unlike human MAOs, bacterial versions are not recognized as therapeutic drug targets, although engineered versions may be used as biocatalysts in chemical synthesis or biosensing.

Other names

Bacterial MAOMAO (bacterial)Flavin-containing amine oxidase (in some annotations)FAD-dependent amine oxidase (bacterial)