Mpox virus antigen (collective; see description) (MPXV antigen (not standardized, used contextually))

Mpox virus antigen is a collective term for molecules derived from the Monkeypox virus (MPXV) that elicit immune recognition, including proteins such as M1R and L1R (essential for viral entry and targets of neutralizing antibodies), A35R and B6R (envelope proteins linked to transmission and virulence), and others present on both forms of the virus (IMV/EEV)[5][6]. These antigens are pivotal in the immune response, serving both as diagnostic markers and as targets for vaccine and therapeutic development[4][5][6]. Vaccines and natural infection induce antibodies and T-cell responses against multiple MPXV antigens. Some viral proteins act as immune evasion factors, interfering with interferon signaling, T cell activation, and antigen presentation[1][3][4]. There is not a single canonical mpox virus antigen, but a diversity of viral proteins collectively termed antigens in scientific and medical contexts[5][6]. If a specific MPXV antigen (e.g., "M1R" or "L1R") is intended, more precise information should be provided; "Mpox virus antigen" is not a single molecule but a general category.

Other names

Monkeypox virus antigenMPXV antigenOrthopoxvirus antigen

Stimulation of immune response by vaccines (neutralizing antibodies, T cell activation); Direct inhibition of viral replication in some cases (e.g., antiviral drugs targeting DNA polymerase or entry proteins)