Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
MSH5-SAPCD1 readthrough (non-protein coding) (MSH5-SAPCD1)
- Target
- MSH5-SAPCD1
- Molecular classification
- Other (non-protein-coding RNA, candidate for NMD)
01
Overview
The MSH5-SAPCD1 readthrough is a chimeric non-coding RNA generated by transcriptional read-through between the MSH5 and SAPCD1 loci. The transcript is a predicted target of nonsense-mediated mRNA decay and is not expected to encode a functional protein. It is classified as a non-coding RNA gene; its biological role, if any, is unknown. Disease associations noted in database records reflect proximity to known disease genes (notably MSH5) rather than independent function or therapeutic relevance for the readthrough itself. There are currently no drugs, validated biomarkers, or known mechanisms of action associated with this transcript[1][3][4][5]. This entry is not a therapeutic target and is likely listed due to confusion with the neighboring, protein-coding MSH5 gene, which is functionally important in DNA repair and meiosis[1][2][3].
- Other names
- MSH5-C6orf26MSH5-C6orf26 readthrough (non-protein coding)MSH5-SAPCD1 readthrough (non-protein coding)
02
Biological functions
No direct known function as it is a non-coding transcriptby inference from related genes, possibly involved in gene regulation events linked to DNA repair or meiosisdirect function is not established
03
Disease associations
Associated (by genetic locus) with Premature Ovarian Failure 13Associated (by genetic locus) with Spermatogenic Failure 74causality is attributed to MSH5, not the readthrough transcript itself
Beyond the preview
Go deeper on MSH5-SAPCD1 readthrough (non-protein coding) (MSH5-SAPCD1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on MSH5-SAPCD1 readthrough (non-protein coding) (MSH5-SAPCD1).