Target intelligence / Profile preview

Mucin 1, cell surface associated (MUC1)

Target: MUC1
Molecular classification: Mucin, Single-pass type I transmembrane glycoprotein

Overview

Mucin 1 (MUC1) is a transmembrane glycoprotein that is heavily O-glycosylated and expressed on the apical surfaces of epithelial cells. It functions as a protective barrier and participates in cell signaling. In cancer, MUC1 is often overexpressed and abnormally glycosylated, contributing to tumor progression. It is also used as a biomarker for certain cancers.

Other names: EpisialinPolymorphic Epithelial Mucin (PEM)H23AgEpithelial Membrane Antigen (EMA)CA15‑3 antigenMammary carcinoma antigen MCA

Biological functions

Barrier protectionLubricationCell signalingAnti-adhesion

Disease associations

Cancer

Safety considerations

Aberrant expression/glycosylation in cancer can promote tumor progression.

Biomarkers

CA15-3 antigen

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