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Target intelligence / Profile preview
Mucin 1 (Tumor-Associated Epitope) (MUC1)
- Target
- MUC1
- Molecular classification
- Glycoprotein, Transmembrane protein, Mucin
01
Overview
Tumor-associated mucin 1 represents an altered form of this mucosal protein characterized by overexpression and abnormal hypoglycosylation in cancers. These changes create unique antigenic determinants that serve as promising targets for antibody-based therapies and cancer vaccines due to their restricted presence on malignant versus normal tissues while playing key roles in oncogenesis through multiple signaling pathways.
- Other names
- TA-MUC1Tumor-associated MUC1MUC1-CCancer antigen 15-3CA 15-3
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC), direct inhibition of oncogenic pathways, induction of immune responses
03
Biological functions
Cell adhesionCell signalingImmune modulationTumor promotionMetastasisDrug resistance
04
Disease associations
CancerAdenocarcinomaBreast cancerOvarian cancerPancreatic cancerLung cancer
05
Safety considerations
Potential for off-target effects due to MUC1 expression in normal tissuesImmune-related adverse eventsDevelopment of resistance
06
Interacting drugs
PankoMab-GEX
2 more in the full profile.
07
Biomarkers
CA 15-3 levels in serum
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