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Target intelligence / Profile preview
Mucin-12, cell surface associated (MUC12)
- Target
- MUC12
- Molecular classification
- Transmembrane mucin, Glycoprotein, EGF-like domain-containing protein, Other
01
Overview
Mucin-12 (MUC12) is an integral membrane glycoprotein belonging to the mucin family, characterized by extensive O-glycosylation, the presence of EGF-like domains, and localization on the epithelial cell surface[1][3][9]. It plays roles in the protection of epithelial cells, modulation of cell adhesion, and cell signaling, and may be involved in regulating epithelial cell growth[1][9]. Expression of MUC12 has been documented in various epithelial tissues, and it has been reported to be down-regulated in certain colorectal cancers[8]. Unlike some more extensively studied mucins, there are no known approved drugs or targeted therapeutics directed at MUC12, nor is it widely used as a clinical biomarker.
- Other names
- MUC12Mucin-12MUC11Mucin-11MUC-12MUC-11mucin-12mucin-11
02
Biological functions
Epithelial cell protectionAdhesion modulationCell signalingRegulation of epithelial cell growthFormation of mucosal barrier
03
Disease associations
Cancer (down-regulated in some colorectal cancers)Other epithelial-related disease (general mucin implication)
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