Multidrug resistance-associated protein 1 (MRP1) and Multidrug resistance-associated protein 7 (MRP7) (MRP1 and MRP7)

Multidrug resistance-associated protein 1 (MRP1/ABCC1) and Multidrug resistance-associated protein 7 (MRP7/ABCC10) are integral membrane proteins belonging to the C subfamily of the ATP-binding cassette (ABC) transporter superfamily (NIH, 2026). These transporters function as energy-dependent efflux pumps, primarily localized on the basolateral membranes of various tissues, including the liver, kidney, and lungs, where they play essential roles in the detoxification and cellular extrusion of xenobiotics and endogenous metabolites like glutathione and glucuronide conjugates (ResearchGate, 2026; NIH, 2026). In oncology, both MRP1 and MRP7 are critical mediators of multidrug resistance (MDR); their overexpression in cancer cells leads to the active removal of diverse chemotherapeutic agents, thereby reducing intracellular drug concentrations and therapeutic efficacy (Frontiers, 2023; NIH, 2026). While MRP1 is well-known for transporting anthracyclines and vinca alkaloids, MRP7 is particularly notable for its ability to efflux taxanes such as docetaxel and paclitaxel, which are often not substrates for other MRP family members (NIH, 2026; ResearchGate, 2026). Targeting these transporters with inhibitors or chemosensitizers, such as tyrosine kinase inhibitors or SSRIs, represents a promising strategy to overcome chemoresistance, although challenges include managing potential drug-drug interactions and the risk of increased toxicity in healthy tissues (Frontiers, 2023; NIH, 2021).

Other names

ABCC1ABCC10ATP-binding cassette subfamily C member 1ATP-binding cassette subfamily C member 10Multidrug resistance-associated protein 1Multidrug resistance-associated protein 7

ATP-dependent efflux of chemotherapeutic agents and physiological substrates across the cell membrane, reducing intracellular drug accumulation.