Multiple growth factor receptors (Platelet-Rich Plasma mediated) (PRP-GFRs)

Multiple endogenous growth factor receptors refer to a diverse set of cell-surface proteins, including Platelet-Derived Growth Factor Receptors (PDGFR), Vascular Endothelial Growth Factor Receptors (VEGFR), and Transforming Growth Factor-Beta Receptors (TGFBR), which are collectively activated by the bioactive molecules found in Platelet-Rich Plasma (PRP) (Marx, 2004). These receptors play a fundamental role in the body's natural healing response by regulating cell proliferation, migration, and the synthesis of extracellular matrix components (Dhurat & Sukesh, 2014). In pathological states such as osteoarthritis, chronic tendinopathy, or non-healing wounds, the activation of these receptors is intended to jump-start the regenerative process and modulate the local inflammatory environment (Andia & Maffulli, 2013). Therapeutic intervention involves the application of autologous PRP, which delivers a high concentration of natural ligands directly to the site of injury to stimulate these endogenous receptors and promote tissue repair (Eppley et al., 2006). While widely used in regenerative medicine, the targeting of multiple receptors via PRP faces challenges due to the inherent variability in platelet concentrations and growth factor profiles among individual patients, leading to inconsistent clinical outcomes (Foster et al., 2009).

Other names

Platelet-rich plasma receptorsPRP-responsive growth factor receptorsPlatelet-derived growth factor receptorsVascular endothelial growth factor receptorsTransforming growth factor-beta receptorsEpidermal growth factor receptorsInsulin-like growth factor receptors

Agonistic activation of multiple endogenous receptor tyrosine kinases and serine/threonine kinase receptors by a concentrated mixture of autologous growth factors (including PDGF, VEGF, TGF-beta, EGF, and IGF-1) released from platelet alpha-granules upon activation (Marx, 2004; Eppley et al., 2006).